Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy
Abstract Background The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression.The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant activation leads to se